Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease

Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease

Blog Article

Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix.GAGs interact with a wide range of proteins, including proteases, growth factors, cytokines, chemokines and adhesion molecules, enabling them to mediate many physiological processes, such as protein function, cellular adhesion and signaling.GAG-protein interactions participate in and intervene in a variety of human c5 corvette radiator support diseases, including cardiovascular disease, infectious disease, neurodegenerative diseases and tumors.

The breakthrough in analytical tools and approaches during the last two decades has facilitated a greater understanding of the importance of GAG-protein interactions and their roles in human diseases.This review focuses on aspects of the molecular basis and mechanisms of GAG-protein interactions involved in human disease.The most recent advances in analytical tools, especially mass spectrometry-based GAG sequencing and binding motif characterization methods, are introduced.

An update of selected families of GAG binding proteins is presented.Perspectives etc ufmp8 on development of novel therapeutics targeting specific GAG-protein interactions are also covered in this review.